I146
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I146
Sigma
IB-MECA
solid, ≥98% (HPLC)
| Synonym: | N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide, 1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β- |
| CAS Number: | 152918-18-8 |
| Linear Formula: | C18H19IN6O4 |
| Molecular Weight: | 510.29 |
| MDL number: | MFCD00671785 |
| PubChem Substance ID: | 24277717 |
Description
| Biochem/physiol Actions | Selective A3 adenosine receptor agonist. |
| Legal Information | Sold under license from the National Institutes of Health. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | hot ethanol: >10 mg/mL |
| DMSO: >5 mg/mL | |
| H2O: insoluble | |
| aqueous acid: insoluble | |
| aqueous base: insoluble | |
| Gene Information | human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) |
| rat ... Adora1(29290), Adora2a(25369), Adora3(25370) | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Von Lubitz, et al., The effects of adenosine A receptor stimulation on seizures in mice. Eur. J. Pharmacol. 275, 23-29, (1995) Abstract |
| Gallo-Rodriguez , et al., Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3 selective adenosine agonists. J. Med. Chem. 37, 636-646, (1994) Abstract | |
| Jacobson, et al., A role for central A3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett. 336, 57-60, (1993) Abstract |
